Abstract The therapeutic landscape in metastatic melanoma has changed dramatically in the last decade. with the success of immune checkpoint inhibitors resulting in durable responses for a large number of patients. For patients with BRAF mutations. combinations of BRAF and MEK inhibitors demonstrated response rates and benefit comparable to those from immune checkpoint inhibitors. https://www.diegojavierfares.com/mega-pick-Jessamine-Orange-Peel-Monrovia-great-pick/